Changes in Pituitary Volume with Bromocriptine (3)	

In sixteen patients with large prolactin-secreting tumours, thirteen showed similar changes. The three patients in whom these changes were not observed consisted of:
• A patient with a pituitary cyst that was associated with a small prolactinoma, but in whom the majority of the pituitary mass was the cyst.
• A patient with an extremely large tumour that was reduced in size but still remained large. (The patient's senum prolactin level fell by ninety per cent but still remained elevated at 328ng/ml (6560mu/l) at the end of nine months of therapy). 
• A patient who had only been treated for six weeks and in whom there was as yet only equivocal evidence of reduction in the size of the tumour.